Structure of PDB 5vja Chain D

Receptor sequence
>5vjaD (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
SMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSVSREEI
EREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDEKESLTED
EATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDVPNPRIKLIDFGIAH
KIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASP
FLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTI
AQSLEHSWIKA
3D structure
PDB5vja Targeting Pim Kinases and DAPK3 to Control Hypertension.
ChainD
Resolution2.46 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D139 K141 E143 N144 D161 T180
Catalytic site (residue number reindexed from 1) D125 K127 E129 N130 D145 T164
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ILE D K276 A277 K260 A261
BS02 DUK D L19 G22 K42 L93 I160 D161 L13 G16 K36 L82 I144 D145
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5vja, PDBe:5vja, PDBj:5vja
PDBsum5vja
PubMed30033129
UniProtO43293|DAPK3_HUMAN Death-associated protein kinase 3 (Gene Name=DAPK3)

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