Structure of PDB 5vdh Chain D

Receptor sequence
>5vdhD (length=343) Species: 9606 (Homo sapiens) [Search protein sequence]
SRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIA
ETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFAN
EKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTC
IMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHY
NTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPAR
VALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYA
AVNFVSRAGTKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY
3D structure
PDB5vdh Crystal Structures of Human GlyR alpha 3 Bound to Ivermectin.
ChainD
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7C6 D P10 L83 D84 L85 D86 P8 L81 D82 L83 D84 BindingDB: EC50=50nM,Kd=11nM
BS02 GLY D F63 R65 S129 F61 R63 S127
BS03 IVM D I225 Q226 I229 P230 I223 Q224 I227 P228
BS04 7C6 D R27 I28 R29 F32 G160 Y161 R25 I26 R27 F30 G158 Y159 BindingDB: EC50=50nM,Kd=11nM
BS05 GLY D F159 Y202 T204 F157 Y200 T202
BS06 IVM D S267 V280 A288 L291 S265 V278 A286 L289
BS07 ZN D E192 D194 H215 E190 D192 H213
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0016594 glycine binding
GO:0022824 transmitter-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5vdh, PDBe:5vdh, PDBj:5vdh
PDBsum5vdh
PubMed28479061
UniProtO75311|GLRA3_HUMAN Glycine receptor subunit alpha-3 (Gene Name=GLRA3)

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