Structure of PDB 5v84 Chain D

Receptor sequence
>5v84D (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
DDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPNYYQIIKAPMDISSMEKK
LNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMK
H
3D structure
PDB5v84 GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2).
ChainD
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 96V D M503 K504 F531 H532 M66 K67 F94 H95 PDBbind-CN: -logKd/Ki=6.70,IC50=0.20uM
BindingDB: IC50=190nM
BS02 96V D P458 F459 V463 Y467 N514 Y520 P21 F22 V26 Y30 N77 Y83 PDBbind-CN: -logKd/Ki=6.70,IC50=0.20uM
BindingDB: IC50=190nM
Gene Ontology
Biological Process
GO:0006338 chromatin remodeling
Cellular Component
GO:0090537 CERF complex

View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:5v84, PDBe:5v84, PDBj:5v84
PDBsum5v84
PubMed28740608
UniProtQ9BXF3|CECR2_HUMAN Chromatin remodeling regulator CECR2 (Gene Name=CECR2)

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