Structure of PDB 5uzc Chain D

Receptor sequence

>5uzcD (length=345) Species: 195103 (Clostridium perfringens ATCC 13124)

NAMARILKTAYTFDDVLLVPNKSEVLPNEVSLKTQLTKKIQLNIPLMSAS
MDTVTESKMAIAMAREGGIGIIHKNMTIEDQAREVDRVKRSGGLLCGASI
GVTNDMMERVDAVVKAKVDVIVLDTAHGHSKGVIEGVKRIKAKYPELQVI
AGNIATPEAVRDLAEAGADCVKVGIGPGSICTTRIVAGVGVPQLTAVMDC
AEEGKKLGIPVIADGGLKYSGDIVKALAAGACAAMMGSIFAGCEEAPGAI
EIYQGRSYKVYRGMGSLGAMAVPEGVEGRIAYKGHLADTIYQLIGGIKSG
MGYLGAPTLENLYENANFVVQTSAGFRESHPHDINITKEAPNYSV

3D structure

• PDB: 5uzc Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P221
• Chain: D
• Resolution: 1.85 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	8N1	D	L24 S436 G439 Y440	L26 S299 G302 Y303
BS02	IMP	D	M49 G300 S301 I302 C303 D336 G338 M358 G359 S360 Y383 G385 M386 G387 E411	M51 G178 S179 I180 C181 D214 G216 M236 G237 S238 Y261 G263 M264 G265 E274
BS03	8N1	D	T247 A248 H249 S252 V255 M386 G387 M392 E411	T125 A126 H127 S130 V133 M264 G265 M270 E274

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0016491 oxidoreductase activity

Biological Process

• GO:0006164 purine nucleotide biosynthetic process

External links

• PDB: RCSB:5uzc, PDBe:5uzc, PDBj:5uzc
• PDBsum: 5uzc
• UniProt: A0A0H2YRZ7