Structure of PDB 5usj Chain D

Receptor sequence
>5usjD (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDG
ETCLLDILDTAGRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKD
SEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDA
FYTLVREIRKHK
3D structure
PDB5usj Multivalent Small-Molecule Pan-RAS Inhibitors.
ChainD
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG D S17 T35 S19 T37
BS02 GNP D D12 G13 G15 K16 S17 A18 F28 V29 D30 Y32 T35 G60 N116 K117 D119 S145 D14 G15 G17 K18 S19 A20 F30 V31 D32 Y34 T37 G62 N111 K112 D114 S140
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5usj, PDBe:5usj, PDBj:5usj
PDBsum5usj
PubMed28235199
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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