Structure of PDB 5uc4 Chain D

Receptor sequence
>5uc4D (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
EEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYES
LTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKS
GTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWE
SSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQF
IGYPITLYL
3D structure
PDB5uc4 Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor.
ChainD
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 83S D L43 N46 A50 D88 G92 M93 F133 T179 L35 N38 A42 D80 G84 M85 F125 T171 MOAD: Kd=0.35uM
BindingDB: Kd=240nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:5uc4, PDBe:5uc4, PDBj:5uc4
PDBsum5uc4
PubMed29382832
UniProtP08238|HS90B_HUMAN Heat shock protein HSP 90-beta (Gene Name=HSP90AB1)

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