Structure of PDB 5tza Chain D

Receptor sequence
>5tzaD (length=333) Species: 9606 (Homo sapiens) [Search protein sequence]
YTKLLHIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYK
IDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLED
IEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQ
AIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKM
AEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQ
GDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAE
LYERVASNREHWTKVSHKFTIRGLPSNNSLDFL
3D structure
PDB5tza Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
ChainD
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7OG D L770 L809 Q812 I826 M847 L858 Q859 F862 L187 L226 Q229 I243 M264 L275 Q276 F279 MOAD: ic50=0.001uM
BindingDB: IC50=1nM
BS02 ZN D H660 H696 D697 D808 H77 H113 D114 D225
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5tza, PDBe:5tza, PDBj:5tza
PDBsum5tza
PubMed28165743
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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