Structure of PDB 5trf Chain D

Receptor sequence
>5trfD (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
TDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQ
YIMTKRLYDQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB5trf SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.
ChainD
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7HC D V14 L54 L57 G58 I61 F86 V93 H96 I99 Y100 V5 L45 L48 G49 I52 F74 V81 H84 I87 Y88 MOAD: Ki=0.88nM
BindingDB: Ki=0.880000nM,Kd=2.7nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5trf, PDBe:5trf, PDBj:5trf
PDBsum5trf
PubMed25145672
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

[Back to BioLiP]