Structure of PDB 5th6 Chain D

Receptor sequence
>5th6D (length=217) Species: 9606 (Homo sapiens) [Search protein sequence]
TDRQLAEEYLYRYGYTRVALGPALLLLQKQLSLPETGELDSATLKAMRTP
RCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFAL
WSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPG
IQGDAHFDDDELWSLGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFT
EGPPLHKDDVNGIRHLY
3D structure
PDB5th6 Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
ChainD
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H401 E402 H405 H411
Catalytic site (residue number reindexed from 1) H175 E176 H179 H185
Enzyme Commision number 3.4.24.35: gelatinase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C99 H401 H405 H411 C52 H175 H179 H185
BS02 ZN D H175 D177 H190 H203 H128 D130 H143 H156
BS03 CA D D165 G197 Q199 D201 D118 G150 Q152 D154
BS04 CA D D182 G183 D185 L187 D205 E208 D135 G136 D138 L140 D158 E161
BS05 CA D D131 D206 E208 D84 D159 E161
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5th6, PDBe:5th6, PDBj:5th6
PDBsum5th6
PubMed28235803
UniProtP14780|MMP9_HUMAN Matrix metalloproteinase-9 (Gene Name=MMP9)

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