Structure of PDB 5t2u Chain D

Receptor sequence
>5t2uD (length=240) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
MELEGLTALVTGGTSGIGLESARLMAAEGADVVITGRDAQRGEQAAADIG
HGARFVQADLGDLDSVADLAAQAPDVDILVNNAGIYPQASTFDQDVAGFQ
QLFDTNVRGTYFLVAAAAKGMVARGHGSIVNITTLAAHKGFPGTSVYGAT
KAALESLTRTWAAEFGANGVRVNSVSPGPTRTPTTLEQLGDFIDDVAAGL
PLRRTAAPEEIAQAVLFLASPRASFVTGSTLYVDGGGYAV
3D structure
PDB5t2u Binding of NADP(+) triggers an open-to-closed transition in a mycobacterial FabG beta-ketoacyl-ACP reductase.
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G16 T134 T144 Y147 K151
Catalytic site (residue number reindexed from 1) G16 T134 T144 Y147 K151
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D G12 G16 I17 R37 D38 R41 D59 L60 N82 Y86 T105 I132 T134 Y147 K151 P177 T180 T182 T184 T185 G12 G16 I17 R37 D38 R41 D59 L60 N82 Y86 T105 I132 T134 Y147 K151 P177 T180 T182 T184 T185
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

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Molecular Function
External links
PDB RCSB:5t2u, PDBe:5t2u, PDBj:5t2u
PDBsum5t2u
PubMed28126742
UniProtA0R723

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