Structure of PDB 5t0u Chain D

Receptor sequence

>5t0uD (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]

HKCHLCGRAFRTVTLLRNHLNTHTGTRPHKCPDCDMAFVTSGELVRHRRY
KHTHEKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYK
LKRHMRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCD
TVIARKSDLGVHLRKQHSY

3D structure

PDB

5t0u Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

3.199 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	T307 Y392 K395 Y407 S419 K423	T14 Y99 K102 Y114 S126 K130
BS02	dna	D	R301 T315 F331 E336 R339 H340 Y343 K344 Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 K405 F416 T417 Q418 T421 H425 I446 R448 D451	R8 T22 F38 E43 R46 H47 Y50 K51 Y65 E69 K72 R75 H76 S79 R84 Y93 R96 K100 R103 H104 K112 F123 T124 Q125 T128 H132 I153 R155 D158
BS03	ZN	D	C296 H312 H316	C3 H19 H23
BS04	ZN	D	C324 C327 H340 H345	C31 C34 H47 H52
BS05	ZN	D	C353 H369 H373	C60 H76 H80
BS06	ZN	D	C381 C384 H397 H401	C88 C91 H104 H108
BS07	ZN	D	C409 C412 H425 H430	C116 C119 H132 H137
BS08	ZN	D	C439 C442 H455 H460	C146 C149 H162 H167

External links

PDB	RCSB:5t0u, PDBe:5t0u, PDBj:5t0u
PDBsum	5t0u
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)

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