Structure of PDB 5t00 Chain D

Receptor sequence

>5t00D (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]

HKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHIR
SHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSGT
MKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIE

3D structure

PDB

5t00 Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

2.19 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	F351 V363 T391 Y392 K395 Y407 S419 K423 K449 S450	F30 V42 T70 Y71 K74 Y86 S98 K102 K128 S129
BS02	dna	D	F331 E336 R339 H340 Y343 K344 E362 K365 R368 S372 R377 Y386 R389 K393 R396 H397 T400 K405 F416 T417 Q418 T421 H425 K429 T444 I446 R448 D451	F10 E15 R18 H19 Y22 K23 E41 K44 R47 S51 R56 Y65 R68 K72 R75 H76 T79 K84 F95 T96 Q97 T100 H104 K108 T123 I125 R127 D130
BS03	ZN	D	C324 C327 H340 H345	C3 C6 H19 H24
BS04	ZN	D	C353 H369 H373	C32 H48 H52
BS05	ZN	D	C384 H397 H401	C63 H76 H80
BS06	ZN	D	C409 C412 H425 H430	C88 C91 H104 H109
BS07	ZN	D	C439 C442 H455 H460	C118 C121 H134 H139

External links

PDB	RCSB:5t00, PDBe:5t00, PDBj:5t00
PDBsum	5t00
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)