Structure of PDB 5slh Chain D

Receptor sequence
>5slhD (length=458) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
PTHLSVDTKFKTEGLCVDIPGIPKDMTYRRLISMMGFKMNYQVNGYPNMF
ITREEAIRHVRAWIGFDVEGCHGTNLPLQLGFSTGVNLVAVPTLMYKGLP
WNVVRIKIVQMLSDTLKNLSDRVVFVLWAHGFELTSMKYFVKIGPERTCC
LCDRRATCFSTASDTYACWHHSIGFDYVYNPFMIDVQQWGFTGNLQSNHD
LYCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWTIEYPIIGDELKINAA
CRKVQHMVVKAALLADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSD
KAYKIEELFYSYHSDKFTDGVCLFWNCNVDRYPANSIVCRFDTRVLSNLN
LPGCDGGSLYVNKHAFHTPAFDKSAFVNLKQLPFFYYSDSPCESHGIDYV
PLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWVYKQFDT
YNLWNTFT
3D structure
PDB5slh PanDDA analysis group deposition
ChainD
Resolution1.819 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D H257 C261 H264 C279 H199 C203 H206 C221
BS02 ZN D C452 C477 C484 H487 C392 C411 C418 H421
BS03 ZN D C207 C210 C226 H229 C149 C152 C168 H171
BS04 LLU D V263 H264 V205 H206
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004532 RNA exonuclease activity
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5slh, PDBe:5slh, PDBj:5slh
PDBsum5slh
PubMed
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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