Structure of PDB 5req Chain D

Receptor sequence
>5reqD (length=619) Species: 1752 (Propionibacterium freudenreichii subsp. shermanii) [Search protein sequence]
TLSLAGDFPKATEEQWEREVEKVLNRGRPPEKQLTFAECLKRLTVHTVDG
IDIVPMYRPKDAPKKLGYPGVAPFTRGTTVRNGDMDAWDVRALHEDPDEK
FTRKAILEGLERGVTSLLLRVDPDAIAPEHLDEVLSDVLLEMTKVEVFSR
YDQGAAAEALVSVYERSDKPAKDLALNLGLDPIGFAALQGTEPDLTVLGD
WVRRLAKFSPDSRAVTIDANIYHNAGAGDVAELAWALATGAEYVRALVEQ
GFTATEAFDTINFRVTATHDQFLTIARLRALREAWARIGEVFGVDEDKRG
ARQNAITSWRELTREDPYVNILRGSIATFSASVGGAESITTLPFTQALGL
PEDDFPLRIARNTGIVLAEEVNIGRVNDPAGGSYYVESLTRSLADAAWKE
FQEVEKLGGMSKAVMTEHVTKVLDACNAERAKRLANRKQPITAVSEFPMI
GARSIETKPFPAAPARKGLAWHRDSEVFEQLMDRSTSVSERPKVFLACLG
TRRDFGGREGFSSPVWHIAGIDTPQVEGGTTAEIVEAFKKSGAQVADLCS
SAKVYAQQGLEVAKALKAAGAKALYLSGAFKEFGDDAAEAEKLIDGRLFM
GMDVVDTLSSTLDILGVAK
3D structure
PDB5req Stabilization of radical intermediates by an active-site tyrosine residue in methylmalonyl-CoA mutase.
ChainD
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) L112 N239 I240 E601 D605 A607
Catalytic site (residue number reindexed from 1) L93 N220 I221 E582 D586 A588
Enzyme Commision number 5.4.99.2: methylmalonyl-CoA mutase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MCD D V42 R45 V23 R26
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004494 methylmalonyl-CoA mutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0016866 intramolecular transferase activity
GO:0031419 cobalamin binding
GO:0046872 metal ion binding
Biological Process
GO:0019652 lactate fermentation to propionate and acetate
GO:0019678 propionate metabolic process, methylmalonyl pathway
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5req, PDBe:5req, PDBj:5req
PDBsum5req
PubMed9772164
UniProtP11652|MUTA_PROFR Methylmalonyl-CoA mutase small subunit (Gene Name=mutA)

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