Structure of PDB 5ovl Chain D

Receptor sequence
>5ovlD (length=228) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
TAGRPAFVSRSVLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPDDLF
GVQCDVTDSAAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFE
EVINTNLTGAFRCAQRASRTMQRKRFGRIIFIGSVSGMWGIGNQANYAAA
KAGLIGMARSISRELAKAGVTANVVAPGYIDTALDFIPAKRVGTAEEVAG
AVSFLASEDASYIAGAVIPVDGGMGMGH
3D structure
PDB5ovl Structural rearrangements occurring upon cofactor binding in the Mycobacterium smegmatis beta-ketoacyl-acyl carrier protein reductase MabA.
ChainD
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G34 S148 Y161 L168
Catalytic site (residue number reindexed from 1) G20 S134 Y147 L154
Enzyme Commision number 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase.
1.1.1.36: acetoacetyl-CoA reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D G30 N32 R33 G34 I35 R55 D69 V70 N96 A97 G98 I99 T119 I146 S148 Y161 K165 P191 G192 I194 G16 N18 R19 G20 I21 R41 D55 V56 N82 A83 G84 I85 T105 I132 S134 Y147 K151 P177 G178 I180
Gene Ontology
Molecular Function
GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0018454 acetoacetyl-CoA reductase activity
GO:0050661 NADP binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0030497 fatty acid elongation
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:5ovl, PDBe:5ovl, PDBj:5ovl
PDBsum5ovl
PubMed29717709
UniProtP71534|MABA_MYCS2 3-oxoacyl-[acyl-carrier-protein] reductase MabA (Gene Name=mabA)

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