Structure of PDB 5nx3 Chain D

Receptor sequence
>5nx3D (length=42) Species: 9606 (Homo sapiens) [Search protein sequence]
ALFFRWYFDVTEGKCAPFVYGGCGGNRNNFDTEEYCMAVCGS
3D structure
PDB5nx3 A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering.
ChainD
Resolution2.296 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D L17 Y22 F23 F33 V34 Y35 G36 C38 G40 N41 R42 N43 C55 L2 Y7 F8 F18 V19 Y20 G21 C23 G25 N26 R27 N28 C40
Gene Ontology
Molecular Function
GO:0004867 serine-type endopeptidase inhibitor activity

View graph for
Molecular Function
External links
PDB RCSB:5nx3, PDBe:5nx3, PDBj:5nx3
PDBsum5nx3
PubMed29934309
UniProtP05067|A4_HUMAN Amyloid-beta precursor protein (Gene Name=APP)

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