Structure of PDB 5npk Chain D

Receptor sequence
>5npkD (length=674) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
KLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEK
ARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHI
RTLLLTFFYRFMRPLIEAGYVYIAQPPTGYKGLGEMNADQLWETTMNPEH
RALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLNERNITSE
MRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKKS
ARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDG
AAAMRFTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNL
LANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPD
FPTAGLILGKSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQ
VNKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVI
LNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRT
QYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKL
SEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLLQ
LVRDELTEIRDRFGDDRRTEIQLG
3D structure
PDB5npk Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.
ChainD
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:5npk, PDBe:5npk, PDBj:5npk
PDBsum5npk
PubMed28507124
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB);
Q99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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