Structure of PDB 5n5s Chain D

Receptor sequence
>5n5sD (length=480) Species: 3218 (Physcomitrium patens) [Search protein sequence]
TPKKYNIFLASKPVDGDRKWLDVTNKYTNDVAAKVPQATHKDIDDAIDAA
VAAAPAMAAMGAYERKAVLEKVVAELKNRFEEIAQTLTMESGKPIKDARG
EVTRTIDTFQVAAEESVRIYGEHIPLDISARNKGLQGIVKKFPIGPVSMV
SPWNFPLNLVAHKVAPAIAVGCPFVLKPASRTPLSALILGEILHKIEELP
LGAFSILPVSREDADMFTVDERFKLLTFTGSGPIGWDMKARAGKKKVVME
LGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDE
VKEGFVAAVKKLKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKL
LTGGNRKGAFIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKEC
NNTHYGLQSGIFTKDLNKAFYAFEHMEVGGVILNDSPALRVDSQPYGGLK
DSGIQREGVKYAMDDMLETKVLVMRNVGTL
3D structure
PDB5n5s The ALDH21 gene found in lower plants and some vascular plants codes for a NADP(+) -dependent succinic semialdehyde dehydrogenase.
ChainD
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N171 K194 E267 C302 E396 E474
Catalytic site (residue number reindexed from 1) N154 K177 E250 C285 E379 E457
Enzyme Commision number 1.2.1.9: glyceraldehyde-3-phosphate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP D V167 S168 P169 W170 N171 L176 K194 S197 R228 A231 T246 G247 S248 I251 E267 L268 C302 E396 F398 Y463 V150 S151 P152 W153 N154 L159 K177 S180 R211 A214 T229 G230 S231 I234 E250 L251 C285 E379 F381 Y446 MOAD: Kd=31uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008911 lactaldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

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Molecular Function
External links
PDB RCSB:5n5s, PDBe:5n5s, PDBj:5n5s
PDBsum5n5s
PubMed28749584
UniProtA9SS48

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