Structure of PDB 5mnv Chain D

Receptor sequence
>5mnvD (length=394) Species: 1890 (Streptomyces antibioticus) [Search protein sequence]
VPAYPFSLPHALDLDPHYAELRRDEPVSRVRLPYGEGTAWLVTRMSDARI
VLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFT
ARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICELLGV
PLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTE
DLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTE
RKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRA
GEPCVVHFASANRDEEVFDHADELDFHRERNPHIAFGHGAHHCIGAQLGR
LELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIRGLERQIVSW
3D structure
PDB5mnv Substrate-induced conformational change in cytochrome P450 OleP.
ChainD
Resolution2.97 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S180 A244 E247 T248 S249 S292 C356 I357 G358 E365 I397
Catalytic site (residue number reindexed from 1) S167 A231 E234 T235 S236 S279 C343 I344 G345 E352 I384
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM D V93 L94 R105 L241 A244 G245 T248 Q252 R298 F321 F349 H354 C356 I357 G358 V80 L81 R92 L228 A231 G232 T235 Q239 R285 F308 F336 H341 C343 I344 G345
BS02 DEB D M83 F84 L94 A244 L396 M70 F71 L81 A231 L383
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5mnv, PDBe:5mnv, PDBj:5mnv
PDBsum5mnv
PubMed30207799
UniProtQ59819

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