Structure of PDB 5mcp Chain D

Receptor sequence

>5mcpD (length=443) Species: 284811 (Eremothecium gossypii ATCC 10895)

TYRDAATALEHLATYAEKDGLSVEQLMDSKTRGGLTYNDFLVLPGKIDFP
SSEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNC
TAEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVT
DDGKPTGKLQGIITSRDIQFVDETLLVSEIMTKDVITGKQGINLEEANQI
LKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGAA
IGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQV
IAGNVVTREQAASLIHAGADGLRIGMGSVMACGRPQGTAVYNVTQFANQF
GVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPIDKGSIKKYI
PYLYNGLQHSCQDIGVRSLVEFREKVDSGSVRFEFRTPSAQLE

3D structure

• PDB: 5mcp A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.
• Chain: D
• Resolution: 2.4 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	D	T165 R167 D168 I188 K208 G209 K210	T164 R166 D167 I186 K206 G207 K208
BS02	ATP	D	I121 P124 V125 F145 G147 K210 M223 S225 T227 D228	I120 P123 V124 F144 G146 K208 M221 S223 T225 D226
BS03	ATP	D	T255 S279 F285	T253 S277 F283

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0005524 ATP binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006177 GMP biosynthetic process
• GO:0006183 GTP biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5mcp, PDBe:5mcp, PDBj:5mcp
• PDBsum: 5mcp
• PubMed: 28572600
• UniProt: Q756Z6