Structure of PDB 5lha Chain D

Receptor sequence
>5lhaD (length=446) Species: 306 (Pseudomonas sp.) [Search protein sequence]
KYKNAEKKFWHPMGSSAAPHRDKTLVIARGDGNYITDIDGQRMLDGVGGL
WNVNIGHNRASVKAAIAAQLDELAYYQTFDGIAHPRVFDLAERLTGMFAQ
ERMARVLFSSGGSDAVETALKMARQYWIASGEPGRTRFLSLRNGYHGVHM
GGTSVGGNGVYHYNHGQLLAGCHLLDTPWLYRNPWDCRDPQALTAHCIRQ
LEEQIALLGAQTIAALIAEPVQGAGGVIVPPADYWPRLREVCDRHGILLI
ADEVVTGFGRSGCMLGSRGWGVAPDILCLAKGITAGYIPLGATLFNQRIA
DAIENGQGFSHMIMHGYTYSGHPTACAAALAVLDIVEAEDLPGNAAKVGA
QLLEQLQPLVERYAVVGEVRGKGLMIALDLVSDKRTRQPLDPAAGQPSRI
ADEARRAGVLVRPIGNKIILSPPLTLTRDEAGLMVSALEAAFARCG
3D structure
PDB5lha Explaining Operational Instability of Amine Transaminases: Substrate-Induced Inactivation Mechanism and Influence of Quaternary Structure on Enzyme-Cofactor Intermediate Stability.
ChainD
Resolution1.89 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y148 D255 K284 T321
Catalytic site (residue number reindexed from 1) Y145 D252 K281 T318
Enzyme Commision number 2.6.1.18: beta-alanine--pyruvate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PMP D G115 S116 Y148 E222 D255 V257 K284 G112 S113 Y145 E219 D252 V254 K281
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0016223 beta-alanine:pyruvate transaminase activity
GO:0030170 pyridoxal phosphate binding

View graph for
Molecular Function
External links
PDB RCSB:5lha, PDBe:5lha, PDBj:5lha
PDBsum5lha
PubMed
UniProtA0A1W2VMW5

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