Structure of PDB 5lba Chain D

Receptor sequence
>5lbaD (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]
DPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL
CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERK
ELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAH
CVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLK
KPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGLSGCGIVYC
RTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVAT
ISFGMGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRN
DRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAI
AKYFGDALPACAKGCDHCQNPTAVRRRLEALERSSSW
3D structure
PDB5lba Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea)
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C411 C427 C431 C434 C395 C411 C415 C418
BS02 ADP D F26 S28 Q34 G55 G57 K58 S59 F16 S18 Q24 G45 G47 K48 S49
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:5lba, PDBe:5lba, PDBj:5lba
PDBsum5lba
PubMed
UniProtO94762|RECQ5_HUMAN ATP-dependent DNA helicase Q5 (Gene Name=RECQL5)

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