Structure of PDB 5lb5 Chain D

Receptor sequence
>5lb5D (length=434) Species: 9606 (Homo sapiens) [Search protein sequence]
DPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL
CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERK
ELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAH
CVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLK
KPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGSGCGIVYCR
TREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATI
SFGVDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDRD
QVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAKY
FGDALPACAKGCDHCQNPTAVRRRLEALERSSSW
3D structure
PDB5lb5 Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
ChainD
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C411 C427 C431 C434 C392 C408 C412 C415
BS02 ADP D F26 K30 Q34 G55 G57 K58 S59 F16 K20 Q24 G45 G47 K48 S49
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:5lb5, PDBe:5lb5, PDBj:5lb5
PDBsum5lb5
PubMed28100692
UniProtO94762|RECQ5_HUMAN ATP-dependent DNA helicase Q5 (Gene Name=RECQL5)

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