Structure of PDB 5l3q Chain D

Receptor sequence
>5l3qD (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTV
TSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGK
STNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKH
GGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPL
MTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRL
IDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAV
VAALMKA
3D structure
PDB5l3q Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex.
ChainD
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP D N427 R458 N96 R127
BS02 AMP D F457 L531 F126 L200
BS03 GNP D N427 G428 G430 K431 S432 T433 N434 R458 K589 D591 G615 G617 Q618 N96 G97 G99 K100 S101 T102 N103 R127 K258 D260 G284 G286 Q287
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005047 signal recognition particle binding
GO:0005525 GTP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0006886 intracellular protein transport
GO:0045047 protein targeting to ER
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005785 signal recognition particle receptor complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5l3q, PDBe:5l3q, PDBj:5l3q
PDBsum5l3q
PubMed27241309
UniProtP08240|SRPRA_HUMAN Signal recognition particle receptor subunit alpha (Gene Name=SRPRA)

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