Structure of PDB 5kl4 Chain D

Receptor sequence

>5kl4D (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]

KPYQCDFKDCERRFSRSDHLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKT
HTRTHTGEKPFSCRWPSCQKKFARSDELVRHHNMHQ

3D structure

PDB

5kl4 Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications.

Chain

Resolution

1.783 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	D	K351 R362 R366 H369 R372 H373 R376 R394 H397 H401 T404 R424 R430	K1 R12 R16 H19 R22 H23 R26 R44 H47 H51 T54 R74 R80
BS02	dna	D	R366 D396 K399 S425	R16 D46 K49 S75
BS03	ZN	D	C355 C360 H373 H377	C5 C10 H23 H27
BS04	ZN	D	C385 C388 H401 H405	C35 C38 H51 H55
BS05	ZN	D	C413 C418 H431 H435	C63 C68 H81 H85
BS06	CA	D	C355 C360	C5 C10

External links

PDB	RCSB:5kl4, PDBe:5kl4, PDBj:5kl4
PDBsum	5kl4
PubMed	27596598
UniProt	P19544\|WT1_HUMAN Wilms tumor protein (Gene Name=WT1)