Structure of PDB 5kkq Chain D

Receptor sequence

>5kkqD (length=145) Species: 9606 (Homo sapiens) [Search protein sequence]

PHKCPDCDMAFVTSGELVRHRRYKHTHEKPFKCSMCDYASVEVSKLKRHI
RSHTGERPFQCSLCSYASRDTYKLKRHMRTHSGEKPYECYICHARFTQSG
TMKMHILQKHTENVAKFHCPHCDTVIARKSDLGVHLRKQHSYIEQ

3D structure

PDB

5kkq Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

1.744 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	D	F351 Y392 Y407 S419 K423 K449 S450	F31 Y72 Y87 S99 K103 K129 S130	PDBbind-CN: Kd=9nM
BS02	dna	D	F331 E336 R339 H340 Y343 K344 Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 T400 K405 F416 Q418 T421 H425 K429 A447 R448 D451	F11 E16 R19 H20 Y23 K24 Y38 E42 K45 R48 H49 S52 R57 Y66 R69 K73 R76 H77 T80 K85 F96 Q98 T101 H105 K109 A127 R128 D131	PDBbind-CN: Kd=9nM
BS03	ZN	D	C324 C327 H340 H345	C4 C7 H20 H25
BS04	ZN	D	C353 C356 H369 H373	C33 C36 H49 H53
BS05	ZN	D	C381 C384 H397 H401	C61 C64 H77 H81
BS06	ZN	D	C409 C412 H425 H430	C89 C92 H105 H110
BS07	ZN	D	C439 C442 H455 H460	C119 C122 H135 H140

External links

PDB	RCSB:5kkq, PDBe:5kkq, PDBj:5kkq
PDBsum	5kkq
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)