Structure of PDB 5jyo Chain D

Receptor sequence
>5jyoD (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]
GSMIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCT
VDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGNK
LFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEY
VGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSI
EVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSG
QFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHD
LVSLCNFHNYD
3D structure
PDB5jyo Structural basis for exploring the allosteric inhibition of human kidney type glutaminase.
ChainD
Resolution2.098 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S286 K289 Y414 Y466 V484
Catalytic site (residue number reindexed from 1) S69 K72 Y194 Y246 V264
Enzyme Commision number 3.5.1.2: glutaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 63J D K320 L321 F322 L323 E325 Y394 K100 L101 F102 L103 E105 Y174 PDBbind-CN: -logKd/Ki=8.52,IC50=0.003uM
BindingDB: IC50=5.0nM,Kd=92nM
Gene Ontology
Molecular Function
GO:0004359 glutaminase activity
Biological Process
GO:0006541 glutamine metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5jyo, PDBe:5jyo, PDBj:5jyo
PDBsum5jyo
PubMed27462863
UniProtO94925|GLSK_HUMAN Glutaminase kidney isoform, mitochondrial (Gene Name=GLS)

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