Structure of PDB 5jy3 Chain D

Receptor sequence
>5jy3D (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQCNKRKVTPWPRDARQQRFAHFTELAIISVQE
IVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLK
DFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSA
DRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTL
SSVHSEQVFALRLQDKKLPPLLSEIWD
3D structure
PDB5jy3 Discovery of Highly Potent Liver X Receptor beta Agonists.
ChainD
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6OX D F268 F271 T272 L274 A275 S278 E281 M312 E315 T316 R319 F329 L330 F340 L345 F349 F37 F40 T41 L43 A44 S47 E50 M81 E84 T85 R88 F98 L99 F109 L114 F118 MOAD: Ki=12nM
BindingDB: EC50=11.0nM,Ki=12nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5jy3, PDBe:5jy3, PDBj:5jy3
PDBsum5jy3
PubMed27994765
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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