Structure of PDB 5jhq Chain D

Receptor sequence

>5jhqD (length=463) Species: 9606 (Homo sapiens) [Search protein sequence]

SGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRK
DVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD
NWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAV
LTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGY
NRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN
AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE
LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCA
VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHK
HGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQ
MGNEAVQQILSES

3D structure

PDB

5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	R215 S217 F222 G225 F226 L250 N255 S258 F259 H261 D279 W281 Y283 E288	R36 S38 F43 G46 F47 L71 N76 S79 F80 H82 D100 W102 Y104 E109
BS02	peptide	D	R368 S370 L375 G378 Y379 L403 N408 Y412 H414 D432 W434 F436 E441	R189 S191 L196 G199 Y200 L224 N229 Y233 H235 D253 W255 F257 E262

External links

PDB	RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum	5jhq
PubMed	27594684
UniProt	O95271\|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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