Structure of PDB 5jdu Chain D

Receptor sequence
>5jduD (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNKGQPSVL
QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGAACEGDSGGPFV
MKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB5jdu Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin.
ChainD
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E192 G193 D194 S195 G196
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D E23 G25 M26 P28 W29 D116 H119 P120 C122 L129C Y134 K135 G136 R137 N159 K202 P204 N205 R206 W207 E8 G10 M11 P13 W14 D113 H116 P117 C119 L129 Y134 K135 G136 R137 N154 K202 P204 N207 R208 W209
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:5jdu, PDBe:5jdu, PDBj:5jdu
PDBsum5jdu
PubMed27347732
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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