Structure of PDB 5j7f Chain D

Receptor sequence
>5j7fD (length=99) Species: 9606 (Homo sapiens) [Search protein sequence]
GAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYI
MTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB5j7f 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.
ChainD
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6GG D M62 Y67 Q72 M51 Y56 Q61 PDBbind-CN: -logKd/Ki=7.24,IC50=0.058uM
BindingDB: Ki=58nM
BS02 6GG D V14 L54 L57 G58 I61 Y67 V93 H96 I99 Y100 V3 L43 L46 G47 I50 Y56 V82 H85 I88 Y89 PDBbind-CN: -logKd/Ki=7.24,IC50=0.058uM
BindingDB: Ki=58nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5j7f, PDBe:5j7f, PDBj:5j7f
PDBsum5j7f
PubMed28482147
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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