Structure of PDB 5izr Chain D

Receptor sequence
>5izrD (length=664) Species: 9606 (Homo sapiens) [Search protein sequence]
QGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFKTKTL
TDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDTEDDICFKVLYDISEVLP
LLRKTFSQEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDELE
LVLKGSYEDTQTSFASAFRFHYMAALETELSGRLYLTVPLRPLTIGKEVT
MDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQVVAKA
LKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCV
TYFSGISGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPER
LASYRRELELRAEQHPTTFVDLWALVLESMLHGQVMDQKLSGQRAALERG
QNPLPLYLSLNEWVEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPE
PRICFLEAIWSNIFSLNEASWLQPGTALAQAFKGFSPNFLQGLQLHQDYE
PRLCLVDAAYFINTSSPSMFRPGRRLDLILSFDYSLSAPFEALQQTELYC
RARGLPFPRVEPSPQDQHQPRECHLFSCPEAPILLHFPLVNASFKDHSAP
GVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFERLLRLSDYNVQTSQ
GAILQALRTALKHR
3D structure
PDB5izr Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
ChainD
Resolution3.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G330 G331 R333 S361 D647
Catalytic site (residue number reindexed from 1) G276 G277 R279 S307 D507
Enzyme Commision number 3.1.1.4: phospholipase A2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7FA D G330 G331 S361 G362 S528 I530 G582 G276 G277 S307 G308 S461 I463 G475
Gene Ontology
Molecular Function
GO:0004620 phospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008970 phospholipase A1 activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047498 calcium-dependent phospholipase A2 activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0009395 phospholipid catabolic process
GO:0016042 lipid catabolic process
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0046475 glycerophospholipid catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5izr, PDBe:5izr, PDBj:5izr
PDBsum5izr
PubMed27220631
UniProtQ86XP0|PA24D_HUMAN Cytosolic phospholipase A2 delta (Gene Name=PLA2G4D)

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