Structure of PDB 5iqg Chain D

Receptor sequence
>5iqgD (length=301) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
RYDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKT
KFSTNKKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEI
KGTFLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQN
VLEEYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSC
NHLLLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILR
MYGNIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTY
K
3D structure
PDB5iqg Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP D G211 I224 K226 Y274 I277 F281 I392 D393 G34 I47 K49 Y97 I100 F104 I215 D216
BS02 51G D D374 S376 D396 Y408 E411 E415 E416 E445 Y448 E451 D197 S199 D219 Y231 E234 E238 E239 E268 Y271 E274
BS03 MG D H379 D393 H202 D216
External links
PDB RCSB:5iqg, PDBe:5iqg, PDBj:5iqg
PDBsum5iqg
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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