Structure of PDB 5iqe Chain D

Receptor sequence
>5iqeD (length=292) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
YDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSDSVAYLVNNEYIFKTKFS
YAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEI
YSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLR
ETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNN
RLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEK
AKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK
3D structure
PDB5iqe Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP D S214 I224 K226 Y274 I277 F281 H379 I392 D393 S34 I44 K46 Y88 I91 F95 H193 I206 D207
BS02 NMY D D374 S376 D396 Y408 E411 E415 E416 E445 Y448 E451 D188 S190 D210 Y222 E225 E229 E230 E259 Y262 E265
BS03 MG D H379 D393 H193 D207
External links
PDB RCSB:5iqe, PDBe:5iqe, PDBj:5iqe
PDBsum5iqe
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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