Structure of PDB 5iqc Chain D

Receptor sequence
>5iqcD (length=290) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
YDDNATNVKAMKYLIEHYFDNFKVDSIEIIGDSVAYLVNNEYIFKTKFSY
AKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGTFLTPEIY
STMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRE
TIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHLLLDGNNR
LTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYGNIDIEKA
KEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTY
3D structure
PDB5iqc Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainD
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP D S214 I224 K226 Y274 E276 I277 F281 H379 I392 D393 S33 I43 K45 Y87 E89 I90 F94 H192 I205 D206
BS02 51G D D374 S376 Y408 E411 E415 E416 E445 Y448 E451 D187 S189 Y221 E224 E228 E229 E258 Y261 E264
BS03 MG D H379 D393 H192 D206
External links
PDB RCSB:5iqc, PDBe:5iqc, PDBj:5iqc
PDBsum5iqc
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

[Back to BioLiP]