Structure of PDB 5iqa Chain D

Receptor sequence
>5iqaD (length=299) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
YDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTK
FSTKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGT
FLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLE
EYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHL
LLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYG
NIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
3D structure
PDB5iqa Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainD
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP D S214 I224 K226 Y274 I277 F281 H379 I392 D393 S36 I46 K48 Y94 I97 F101 H199 I212 D213
BS02 MG D H379 D393 H199 D213
External links
PDB RCSB:5iqa, PDBe:5iqa, PDBj:5iqa
PDBsum5iqa
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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