Structure of PDB 5igq Chain D

Receptor sequence
>5igqD (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
EFQECLSKFTRYNSVRPLATLSYALYNGSSIVSSIEFDRDCDYFAIAGVT
KKIKVYEYDTVIQDAIHYPENEMTCNSKISCISWSSYHKNLLASSDYEGT
VILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTN
LDNSVASIEAKANVCCVKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMV
FKGHRKAVSYAKFVSGEEIVSASTDSQLKLWNVGKPYCLRSFKGHINEKN
FVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVNEFVSAVCWRA
LPDGESNVLIAANSQGTIKVLELV
3D structure
PDB5igq Structural Basis for Substrate Selectivity of the E3 Ligase COP1.
ChainD
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide D V441 K472 Y491 W517 N557 C559 H578 A601 T618 K643 N644 F645 V49 K78 Y97 W123 N163 C165 H184 A207 T224 K249 N250 F251
Gene Ontology
Molecular Function
GO:0061630 ubiquitin protein ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5igq, PDBe:5igq, PDBj:5igq
PDBsum5igq
PubMed27041596
UniProtQ8NHY2|COP1_HUMAN E3 ubiquitin-protein ligase COP1 (Gene Name=COP1)

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