Structure of PDB 5iez Chain D

Receptor sequence
>5iezD (length=146) Species: 9606 (Homo sapiens) [Search protein sequence]
DDELYRQSLEIISRYLREQATGAKDGATSRKALETLRRVGDGVQRNHETA
FQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKH
LKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
3D structure
PDB5iez Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
ChainD
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6AL D H224 A227 F228 M231 L246 M250 R263 T266 L267 F270 G271 H47 A50 F51 M54 L69 M73 R86 T89 L90 F93 G94 BindingDB: Ki=23nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5iez, PDBe:5iez, PDBj:5iez
PDBsum5iez
PubMed27878989
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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