Structure of PDB 5icr Chain D

Receptor sequence
>5icrD (length=609) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
FIKDGQIKFPSSIVAHVERWAKVRGDKLAYRFLDFSTERDGVPRDLTWAQ
FSARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAVPLF
DPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTRPANQRPRVIA
VDAVPDDVASTWVNPDEPDETTIAYLQYTSTRIPTGVQITHLNLATNVVQ
VIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVRRP
ERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAV
LNGSEPISAATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEE
PKIITVDRDQLNSGRIVEVDADSPKAVAQASAGKVGIAEWAVIVDAESAT
ELPDGQVGEIWISGQNMGTGYWGKPEESVATFQNILKSRTNPSHAEGATD
DATWVRTGDYGAFYDGDLYITGRVKDLVIIDGRNHYPQDLEYSAQEASKA
IRTGYVAAFSVPANQLPDEVDPDDTSEQLVIVAERAPGAHKLDIGPITDD
IRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACRAAYLDGSLRAGK
VANDFPDAT
3D structure
PDB5icr 2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine.
ChainD
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N207 H231 A346
Catalytic site (residue number reindexed from 1) N197 H221 A336
Enzyme Commision number 6.2.1.20: long-chain-fatty-acid--[acyl-carrier-protein] ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 649 D L215 H231 D232 T237 L240 I278 S314 E315 P316 S342 Y343 G344 L345 L350 D469 I480 R483 K601 L205 H221 D222 T227 L230 I268 S304 E305 P306 S332 Y333 G334 L335 L340 D459 I470 R473 K581
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008922 long-chain fatty acid [acyl-carrier-protein] ligase activity
GO:0016874 ligase activity
GO:0070566 adenylyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5icr, PDBe:5icr, PDBj:5icr
PDBsum5icr
PubMed
UniProtA0R618|FAA32_MYCS2 Long-chain-fatty-acid--AMP ligase FadD32 (Gene Name=fadD32)

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