Structure of PDB 5hp3 Chain D

Receptor sequence
>5hp3D (length=397) Species: 9606 (Homo sapiens) [Search protein sequence]
TPSRQPIPSEGLQLHLPQVLADAVSRLVLGKFGDLTDNFSSPHARRKVLA
GVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSL
LRFLYTQLELYLNNKDDQKRSIFQKSERGGFRLKENVQFHLYISTSPCGD
ARIFSPHEPILEEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWD
GVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHG
DHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWT
VGDSAIEVINATTGKDELGRASRLCKHALYCRWMRVHGKVPSHLLRSKIT
KPNVYHESKLAAKEYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSLT
3D structure
PDB5hp3 Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity.
ChainD
Resolution3.091 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.37: double-stranded RNA adenine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP D N391 I397 R401 K519 R522 S531 K629 Y658 K662 Y668 K672 E689 K690 N88 I94 R98 K216 R219 S228 K326 Y355 K359 Y365 K369 E386 K387
BS02 ZN D H394 C451 C516 H91 C148 C213
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004000 adenosine deaminase activity
Biological Process
GO:0006396 RNA processing

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5hp3, PDBe:5hp3, PDBj:5hp3
PDBsum5hp3
PubMed27065196
UniProtP78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (Gene Name=ADARB1)

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