Structure of PDB 5h2u Chain D

Receptor sequence
>5h2uD (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
MERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQ
SEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRSDEKVL
PVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLA
RLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRG
QVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPTF
KALRERLSSFTSHH
3D structure
PDB5h2u Co-crystal structures of PTK6: With Dasatinib at 2.24 angstrom , with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 angstrom resolution
ChainD
Resolution2.24 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D312 A314 R316 N317 D330 I349
Catalytic site (residue number reindexed from 1) D128 A130 R132 N133 D146 I165
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 D L197 A217 K219 L248 I262 T264 M267 A268 G270 L319 D330 L14 A34 K36 L65 I79 T81 M84 A85 G87 L135 D146 MOAD: ic50=7nM
BindingDB: Kd=7.8nM,IC50=5.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5h2u, PDBe:5h2u, PDBj:5h2u
PDBsum5h2u
PubMed27993680
UniProtQ13882|PTK6_HUMAN Protein-tyrosine kinase 6 (Gene Name=PTK6)

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