Structure of PDB 5gs9 Chain D

Receptor sequence
>5gs9D (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
MELHILEHRVRVLSVARPGLWLYTHPLIKLLFLPRRSRCKFFSLTETPED
YTLMVDEEGFKELPPSEFLQVAEATWLVLNVSSQAAGVTKIARSVIAPLA
EHHVSVLMLSTYQTDFILVREQDLSVVIHTLAQEFDIYREVGGEPVPVPS
PTVHPIQSPQNRFCVLTLDPETLPAIATTLIDVLFYSHSITFFAFSLIEG
YISIVMDAETQKKFPSDLLLTSGELWRMVRIGGQPLGFDECGIVAQIAGP
LAAADISAYYISTFNFDHALVPEDGIGSVIEVLQRR
3D structure
PDB5gs9 Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signaling.
ChainD
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ARG D V112 L113 L273 G274 E277 I280 V281 T300 F301 F303 D304 V106 L107 L236 G237 E240 I243 V244 T263 F264 F266 D267 MOAD: Kd=5.5uM
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0034618 arginine binding
GO:0042802 identical protein binding
GO:0140299 molecular sensor activity
GO:0140311 protein sequestering activity
Biological Process
GO:0034198 cellular response to amino acid starvation
GO:1903577 cellular response to L-arginine
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0061700 GATOR2 complex

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Cellular Component
External links
PDB RCSB:5gs9, PDBe:5gs9, PDBj:5gs9
PDBsum5gs9
PubMed27648300
UniProtQ8WTX7|CAST1_HUMAN Cytosolic arginine sensor for mTORC1 subunit 1 (Gene Name=CASTOR1)

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