Structure of PDB 5g2t Chain D

Receptor sequence
>5g2tD (length=464) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
EKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPL
SQPSRAALWSGMMPHQTNVRSNSSEPVNTRLPENVPTLGSLFSESGYEAV
HFGKTHDMGSLRGFKHKEPVAKPFTDPEFPVNNDSFLDVGTCEDAVAYLS
NPPKEPFICIADFQNPHNICGFIGENAGVHTDRPISGPLPELPDNFDVED
WSNIPTPVQYICCSHRRMTQAAHWNEENYRHYIAAFQHYTKMVSKQVDSV
LKALYSTPAGRNTIVVIMADHGDGMASHRMVTKHISFYDEMTNVPFIFAG
PGIKQQKKPVDHLLTQPTLDLLPTLCDLAGIAVPAEKAGISLAPTLRGEK
QKKSHPYVVSEWHSEYEYVTTPGRMVRGPRYKYTHYLEGNGEELYDMKKD
PGERKNLAKDPKYSKILAEHRALLDDYITRSKDDYRSLKVDADPRCRNHT
PGYPSHEGPGAREI
3D structure
PDB5g2t How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans.
ChainD
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D32 H33 S72 R76 K125 H127 N153 H188 D291 H292 K304
Catalytic site (residue number reindexed from 1) D11 H12 S51 R55 K104 H106 N132 H167 D270 H271 K283
Enzyme Commision number 3.1.6.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D C233 C234 H470 H477 C212 C213 H449 H456
BS02 UAP D S72 N93 K125 H127 H188 C191 R238 K304 E386 Y387 S51 N72 K104 H106 H167 C170 R217 K283 E365 Y366
Gene Ontology
Molecular Function
GO:0004065 arylsulfatase activity
GO:0015024 glucuronate-2-sulfatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5g2t, PDBe:5g2t, PDBj:5g2t
PDBsum5g2t
PubMed28630303
UniProtQ8A7C8|HEXSF_BACTN Delta 4,5-hexuronate-2-O-sulfatase (Gene Name=BT_1596)

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