Structure of PDB 5fmz Chain D

Receptor sequence

>5fmzD (length=715) Species: 1601067 (Influenza B virus (B/Memphis/13/2003))

SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYTANLRPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYL
ADLFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLS
NESSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDVEKGIDFKLGQT
ISRLRDISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKL
TWEDLRPIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAK
ECLEKYSTLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQ
KTNYAKWATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEM
NLLSTLTSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMK
YVLFHTSLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHL
RGDTDVVTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYC
RVNGTNKIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGD
RVNSPKTFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAE
SRRLLLLIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWL
GFEKEGSKVLESVDE

3D structure

• PDB: 5fmz Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of Pb2 Domains.
• Chain: D
• Resolution: 3.4 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	D	K330 A365 T366 G367 G369 L370 T371 Y372 P394 H506 R508 V513 T515 R558 V559 N560 G561 T562 Q566	K323 A358 T359 G360 G362 L363 T364 Y365 P387 H499 R501 V506 T508 R551 V552 N553 G554 T555 Q559

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:5fmz, PDBe:5fmz, PDBj:5fmz
• PDBsum: 5fmz
• PubMed: 26711008
• UniProt: Q5V8Z9