Structure of PDB 5fjv Chain D

Receptor sequence
>5fjvD (length=204) Species: 9606 (Homo sapiens) [Search protein sequence]
EDRLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTN
VWLKQEWSDYKLRWNPTDFGNITSLRVPSEMIWIPDIVLYNNADGEFAVT
HMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFDQQNCKMKFGSWTYDKAKI
DLEQMEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVTYAFVI
RRLP
3D structure
PDB5fjv Crystal Structure of a Human Neuronal Nachr Extracellular Domain in Pentameric Assembly: Ligand-Bound Alpah2 Homopentamer.
ChainD
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EPJ D W84 A137 H138 V148 W52 A105 H106 V116 BindingDB: Ki=10.2nM
BS02 EPJ D Y122 W178 T179 Y219 C222 Y226 Y90 W143 T144 Y184 C187 Y191 BindingDB: Ki=10.2nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:5fjv, PDBe:5fjv, PDBj:5fjv
PDBsum5fjv
PubMed27493220
UniProtQ15822|ACHA2_HUMAN Neuronal acetylcholine receptor subunit alpha-2 (Gene Name=CHRNA2)

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