Structure of PDB 5ewm Chain D

Receptor sequence
>5ewmD (length=355) Species: 9606 (Homo sapiens) [Search protein sequence]
PPSIGIAVILVGTSDEVAIKDFHHLSVVPRVELVAMNETDPKSIITRICD
LMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPILGIHGGSSMIMADK
DESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVNKIR
STIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEA
TYIFEVANSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDY
GLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNR
YLINVTFEDLSFSEDGYQMHPKLVIILLNKERKWERVGKWKDKSLQMKYY
VWPRM
3D structure
PDB5ewm A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
ChainD
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5SM D P78 Q110 I111 F114 A135 P177 P41 Q73 I74 F77 A98 P140 BindingDB: IC50=12nM
External links
PDB RCSB:5ewm, PDBe:5ewm, PDBj:5ewm
PDBsum5ewm
PubMed26912815
UniProtQ13224|NMDE2_HUMAN Glutamate receptor ionotropic, NMDA 2B (Gene Name=GRIN2B)

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