Structure of PDB 5egu Chain D

Receptor sequence
>5eguD (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
MNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKL
NLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKP
GDDIVLMAEALEKLFLQKINELPT
3D structure
PDB5egu Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.
ChainD
Resolution2.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5NQ D P82 F83 Q85 V87 D88 L92 L94 N140 I146 P40 F41 Q43 V45 D46 L50 L52 N98 I104 MOAD: Kd=1.4uM
BindingDB: IC50=5000nM,Kd=1400nM
External links
PDB RCSB:5egu, PDBe:5egu, PDBj:5egu
PDBsum5egu
PubMed26735842
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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