Structure of PDB 5efb Chain D

Receptor sequence
>5efbD (length=355) Species: 7955 (Danio rerio) [Search protein sequence]
PITGLVYDQRMMLHHNMWDSHHPELPQRISRIFSRHEELRLLSRCHRIPA
RLATEEELALCHSSKHISIIKSSEHMKPRDLNRLGDEYNSIFISNESYTC
ALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTAAL
TARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGA
FFPNSEDANYDKVGLGKGRGYNVNIPWNGGKMGDPEYMAAFHHLVMPIAR
EFAPELVLVSAGFDAARGDPLGGFQVTPEGYAHLTHQLMSLAAGRVLIIL
EGGYNLTSISESMSMCTSMLLGDSPPSLLTPLKTSATVSINNVLRAHAPF
WSSLR
3D structure
PDB5efb Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.
ChainD
Resolution2.543 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN D D612 H614 D705 D171 H173 D264
BS02 5OK D H463 S531 H573 H574 F583 D612 H614 F643 L712 Y745 H22 S90 H132 H133 F142 D171 H173 F202 L271 Y304 PDBbind-CN: -logKd/Ki=8.37,Ki=4.3nM
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