Structure of PDB 5ebu Chain D

Receptor sequence
>5ebuD (length=353) Species: 1377 (Aerococcus viridans) [Search protein sequence]
IEYNAPSEIKYIDVVNTYDLEEEASKVVPHGGFNYIAGASGDEWTKRAND
RAWKHKLLYPRLAQDVEAPDTSTEILGHKIKAPFIMAPIAAHGLAHATKE
AGTARAVSEFGTIMSISAYSGATFEEISEGLNGGPRWFQIYMAKDDQQNR
DILDEAKGDGATAIILTADSTVSGNRDRDVKNKFVYPFGMPIVQGASKQK
ISPRDIEEIAAHSGLPVFVKGIQHPEDADMAIKAGASGIWVSNHGARQLY
EAPGSFDTLPAIAERVNKRVPIVFDSGVRRGEHVAKALASGADVVALGRP
VLFGLALGGWQGAYSVLDYFQKDLTRVMQLTGSQNVEDLKGLDLFDNPYG
YEY
3D structure
PDB5ebu Conformational flexibility related to enzyme activity: evidence for a dynamic active-site gatekeeper function of Tyr(215) in Aerococcus viridans lactate oxidase.
ChainD
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S122 Y146 T172 D174 K241 H265
Catalytic site (residue number reindexed from 1) S117 Y141 T167 D169 K220 H244
Enzyme Commision number 1.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN D I41 P93 I94 A95 Q144 Y146 T172 K241 H265 G266 R268 D296 S297 G298 R300 G319 R320 I36 P88 I89 A90 Q139 Y141 T167 K220 H244 G245 R247 D275 S276 G277 R279 G298 R299
BS02 PYR D Y40 H265 Y35 H244
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004459 L-lactate dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ebu, PDBe:5ebu, PDBj:5ebu
PDBsum5ebu
PubMed27302031
UniProtQ44467|LOX_AERVM L-lactate oxidase

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