Structure of PDB 5e26 Chain D

Receptor sequence
>5e26D (length=360) Species: 9606 (Homo sapiens) [Search protein sequence]
RPLFPWFGLDIGGTLVKLVYFEPKDITAEEEEEEVESLKSIRKYLTSNVA
YGSTGIRDVHLELKDLTLCGRKGNLHFIRFPTHDMPAFIQMGRDKNFSSL
HTVFCATGGGAYKFEQDFLTIGDLQLCKLDELDCLIKGILYIDSVGFNGR
SQCYYFENPADSEKCQKLPFDLKNPYPLLLVNIGSGVSILAVYSKDNYKR
VTGTSLGGGTFFGLCCLLTGCTTFEEALEMASRGDSTKVDKLVRDIYGGD
YERFGLPGWAVASSFGNMMSKEKREAVSKEDLARATLITITNNIGSIARM
CALNENINQVVFVGNFLRINTIAMRLLAYALDYWSKGQLKALFSEHEGYF
GAVGALLELL
3D structure
PDB5e26 Crystal structure of human PANK2: the catalytic core domain in complex with pantothenate and adenosine diphosphate
ChainD
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAU D E338 V394 R407 G410 T411 E131 V187 R200 G203 T204
BS02 ADP D G219 G220 T221 L222 K224 G391 S392 G415 G416 F431 N522 R525 G12 G13 T14 L15 K17 G184 S185 G208 G209 F224 N315 R318
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0015937 coenzyme A biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5e26, PDBe:5e26, PDBj:5e26
PDBsum5e26
PubMed
UniProtQ9BZ23|PANK2_HUMAN Pantothenate kinase 2, mitochondrial (Gene Name=PANK2)

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